Thursday, November 24, 2022
HomeTechnologyInnovative transdermal delivery of insulin using gelatin methacrylate-based Microneedle Patches in Mice...

Innovative transdermal delivery of insulin using gelatin methacrylate-based Microneedle Patches in Mice and Mini-pigs

Painless and controlled on-demand drug delivery is the ultimate goal for the management of various chronic diseases, including diabetes. To achieve this purpose, microneedle patches are gaining increased attention. While degradable microneedle (MN) arrays are widely employed, the use of non-dissolving MN patches remains a challenge to overcome. In this study, we demonstrate that cross-linking gelatin methacrylate with polyethylene glycol diacrylate (PEGDA) is potent for engineering non dissolving MN arrays. Incorporation of MoS2 nanosheets as a photothermal component into the MN hydrogels results in MNs featuring on-demand release properties. An optimized MoS2-MN array patch formed using a hydrogel solution containing 500 µg/mL of MoS2 and photochemically crosslinked for 5 min have required mechanical behavior under a normal compressive load to penetrate the stratum corneum of mice or pig skin and allow delivery of macromolecular therapeutics such as insulin upon swelling. Using ex-vivo and in-vivo models, we show that the MoS2-MN patches can be used for loading and releasing insulin for therapeutic purpose. Indeed, transdermal administration of insulin loaded into MoS2-MN patch reduces blood glucose levels in C57BL/6 mice and mini-pigs comparable to subcutaneously injected insulin. We believe that this on demand delivery system might alter current insulin therapies and might be a potential approach for the delivery of other proteins.



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